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Now Trending Green, (Nasdaq: CRDL) Continues Its Hold On My Top Watchlist Spot



*Disseminated on Behalf of Cardiol Therapeutics Inc.


Now Trending Green, (Nasdaq: CRDL) Continues Its Hold On My Top Watchlist Spot


August 22nd

Greetings, Friend!


Cardiol Therapeutics Inc. (Nasdaq: CRDL) just pushed green and is currently sitting atop our watchlist.


Making a run of approx. 51% from a $.93+ low on August 8th to a high of $1.41+ on August 15th, CRDL's chart demonstrated its volatile potential.


And with CRDL maintaining above key $1.00 psychological resistance since August 12th, it's hard not wanting to consider this Nasdaq idea for a spot on your radar.


Could support be growing at that $1.00 level?


With multiple analyst targets pointing to triple-digit upside potential, CRDL may be undervalued from its current chart positioning.


Take a moment to review my initial (Nasdaq: CRDL) report below and consider it for your radar.

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Critical progress is being made in cardiovascular medicine, with a strong emphasis on therapies that address inflammatory heart conditions—areas where few treatments currently exist despite significant patient need.


Research efforts targeting diseases such as pericarditis and myocarditis are beginning to show encouraging results, as clinical programs move closer to providing potential new options for those affected by these challenging conditions.


Driving this work is a dedicated life sciences company, led by seasoned experts and united by a clear focus on tackling some of the most urgent issues in cardiac health.


With new initiatives underway in fields like heart failure, the achievements of this team could start gaining increased attention across the medical community—highlighting a story that matters to anyone watching meaningful change in hea.lthcare.


And with topline results dropping recently and multiple analyst targets pointing to triple-digit potential upside, this under-the-radar Nasdaq profile has risen quickly to the top of my watchlist.


Consider checking out:


*Cardiol Therapeutics Inc. (Nasdaq: CRDL)*


Cardiol Therapeutics Inc. is a clinical-stage life sciences company focused on developing anti-inflammatory and anti-fibrotic therapies for the treatment of heart disease.


And based on several potential catalysts, (Nasdaq: CRDL) takes over Monday's watchlist's top spot. Check them out:


#1. Advancing Therapies That Target Inflammation In The Heart!


#2. Cardiol Therapeutics Enrolling Patients In A Pivotal Phase III MAVERIC Trial.


#3. Cardiol Therapeutics Announced Phase II Topline Results.


#4. Multiple Analyst Targets Point To Triple-Digit Potential Upside!


But more on those in a second...


Cardiol's Immediate Focus


The company is focused on understanding how inflammation and fibrosis contribute to diseases of the heart and to develop therapies, now in clinical trials for rare cardiac conditions, to target these mechanisms and promote healing.


Pericarditis


Pericarditis is the most common form of pericardial disease with a prevalence of 160,000 in the United States; following an initial episode, 15 – 30% of patients experience a recurrence.


Pericarditis refers to inflammation of the membrane or sac that surrounds the heart (the pericardium) that is most frequently triggered from a viral infection. Recurrent pericarditis is the most common complication following an initial acute episode of pericarditis, and patients may have multiple recurrences. Symptoms include debilitating chest pain, shortness of breath, and fatigue, resulting in physical limitations, reduced quality of life, emergency department visits, and hospitalizations. Infrequent but life-threatening complications associated with pericarditis include a large accumulation of pericardial fluid, scarring, and constriction of the heart which may limit heart function. The disease is diagnosed in 0.2% of all cardiovascular in-hospital admissions and is responsible for 5% of emergency room admissions for chest pain in North America and Western Europe.


Cardiol’s MAVERIC program for recurrent pericarditis has two parts. The first, a Phase II study, is already completed. The second, a larger pivotal Phase III trial, is still enrolling patients. This global study will show if CardiolRx™ can stop the disease from coming back in high-risk patients and help get it approved by regulators.

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Myocarditis


Acute myocarditis is a leading cause of sudden cardiac death in people under 35 years of age.


Myocarditis is when the heart muscle gets inflamed. It can cause chest pain, trouble with how the heart works, and abnormal heart rhythms. In some cases, it can lead to severe heart failure or even sudden death, especially in people under 35.


Most often, it’s caused by a vi-rus, but it can also come from bacteria, certain medications, mRNA vaccines, or cancer treatments like chemotherapy and immune-

based drugs.


CardiolRx™ was tested in the ARCHER trial, a Phase II study which took place in the US, Canada, Brazil, France, and Israel. The goal was to see if the drug is safe, well tolerated, and helps the heart recover in people with acute myocarditis. The topline results were just announced!

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Heart Failure


Heart failure affects more than 64 million people globally and associated heal.thcare costs exceed $30Bn annually in the U.S. alone.


Heart failure is when the heart can’t pump enough blood and oxygen for the body. This can cause shortness of breath, a fast heartbeat, swelling, low energy, and trouble doing everyday activities. Many people with heart failure end up in the hospital often, and it can greatly affect quality of life.


It can be caused by heart attacks, high blood pressure, heart valve problems, heart inflammation (like myocarditis), certain cancer treatments, or inherited conditions.


CRD-38 is Cardiol’s new subcutaneously administered drug formulation for heart failure. They’re doing the prep work needed before starting clinical trials to see if it can become a new treatment option.

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Product Pipeline

Therapeutic Development - CardiolRx™


CardiolRx™ is an oral treatment in development for serious heart diseases. It works by blocking several inflammation pathways, including the NLRP3 inflammasome, a key driver of the inflammation and scarring seen in pericarditis, myocarditis, and heart failure.


The drug is made to the highest pharmaceutical standards (cGMP) to ensure purity, consistency, and stability. In clinical trials, CardiolRx™ continues to show a profile that is safe and well tolerated, with no serious side effects.


These strong safety results helped Cardiol w-in FDA approvals to run Phase II and Phase III trials in rare heart conditions — recurrent pericarditis and acute myocarditis — giving the company a direct path toward targeting high-value, underserved markets.

The United States Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for CardiolRx™ for the treatment of pericarditis, which includes recurrent pericarditis. CardiolRx™ is also eligible for FDA ODD in acute myocarditis and European Medicine Agency orphan medicine designations for recurrent pericarditis and acute myocarditis.


Grab Sources And More: CRDL Website. CRDL Presentation.

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And as I mentioned earlier, (Nasdaq: CRDL) has several potential catalysts to consider. Take a look:


#1. CRDL Potential Catalyst - Advancing Therapies that Target Inflammation in the Heart!


Cardiol Therapeutics is developing CardiolRx™, an oral cannabidiol therapy, to treat heart conditions like recurrent pericarditis and acute myocarditis by targeting inflammation.


Promising Phase II results for CardiolRx™ showed improved heart function and reduced inflammation, with ongoing Phase III MAVERIC trials further evaluating its potential in preventing pericarditis recurrence. 


The company is also advancing CRD-38, a novel subcutaneous drug for heart failure, addressing a critical global health issue.


These therapies demonstrate strong clinical promise and excellent safety profiles.

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#2. CRDL Potential Catalyst - Enrolling Patients In A Pivotal Phase III MAVERIC Trial.


Cardiol Therapeutics enrolled the first patient in its pivotal Phase III MAVERIC trial, assessing CardiolRx™ for preventing recurrent pericarditis, earlier this year. 


This randomized, double-blind, placebo-controlled study involves around 110 patients across the US, Canada, and Europe. CardiolRx™, an FDA Orphan Drug-designated oral therapy targeting inflammasome activation, showed in Phase II study significant reductions in pericarditis pain, inflammation, and recurrence rates.


With no widely accessible non-immunosuppressive option currently available, MAVERIC’s outcomes could support a New Drug Application, potentially transforming treatment for patients suffering recurrent pericarditis and addressing a major unmet medical need.

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#3. CRDL Potential Catalyst - Cardiol Therapeutics Announced Phase II Topline Results.


Cardiol Therapeutics' Phase II ARCHER trial in acute myocarditis showed that CardiolRx™ notably improved a key heart parameter (LV extracellular volume), trending toward statistical significance and accompanied by significant LV mass reduction.


Multiple cardiac MRI endpoints favored CardiolRx™ over placebo, supporting the drug’s effectiveness.


The therapy demonstrated an excellent safety profile and was well tolerated.


These compelling results provide strong clinical proof of concept, encouraging further development of CardiolRx™ and CRD-38 for heart conditions including myocarditis and heart failure.

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#4. CRDL Potential Catalyst - Multiple Analyst Targets Point To Triple-Digit Potential Upside!


Take a look at what we found over at TipRanks:

In case you can't see the fine print, it shares at least 4 separate analysts have provided targets within the last 12 months.


Each of their targets points to CRDL possessing over triple-digit potential upside from the chart setup observed at the close on Thursday.

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(Nasdaq: CRDL) Recap - These 4 Potential Catalysts Lead Our Research


#1. Advancing Therapies That Target Inflammation In The Heart!


#2. Cardiol Therapeutics Enrolling Patients In A Pivotal Phase III MAVERIC Trial.


#3. Cardiol Therapeutics Announced Phase II Topline Results.


#4. Multiple Analyst Targets Point To Triple-Digit Potential Upside!

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Cardiol Therapeutics Inc. (CRDL) has quickly climbed my watchlist to earn the top spot.


Keep your eyes peeled for updates coming soon.


All the best,

Dane James

Editor Market Pulse Today


(Remember: St-ock Prices Could Be Significantly Lower Now From The Original Dates I Provided.)


*MarketPulseToday.com (“MarketPulseToday” or “MPT” ) is owned by Thousand Sun Media LLC, MPT is not responsible for its accuracy. Make sure to always do your own research and due diligence on any day and swing profile MPT brings to your attention. Any emojis used do not have a specific defined meaning, and may be used inconsistently. We do not provide personalized in-vest-ment advice, are not in-vest-ment advisors, and any profiles we mention are not suitable for all in-vest-ors.


Pursuant to an agreement between Thousand Sun Media LLC and TD Media LLC, Thousand Sun Media LLC has been hired for a period beginning on 08/21/2025 and ending on 08/25/2025 to publicly disseminate information about (CRDL:US) (CRDL:CA) via digital communications. Under this agreement, Thousand Sun Media LLC has been paid seven thousand five hundred USD ("Funds"). These Funds were part of the funds that TD Media LLC received from a third party who did not receive the Funds directly or indirectly from the Issuer and does not own st-ock in the Issuer but the reader should assume that the clients of the third party own shares in the Issuer, which they will liquidate at or near the time you receive this communication and has the potential to hurt share prices.


Neither Thousand Sun Media LLC, TD Media LLC and their member own shares of (CRDL:US) (CRDL:CA).


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